That depends on what it is about C# that you need, and which needs replacing.
If the reason you use C# is that you need a reasonably high performance statically typed language then no, IronPython is likely not going to be a replacement.
If the reason you use it is simply "I need something that runs on .NET and can access .NET libraries", then yes, any language that runs on .NET can be used to replace it.
If you use C# because you're working with a team of programmers who only know C-like languages, C# might also be difficult to replace with IronPython.
It depends on what characteristics about C# it is that you care about, and need to find replacements for.